Silsesquioxane polymer as a potential scaffold for laryngeal reconstruction
- Submitting institution
-
The Open University
- Unit of assessment
- 12 - Engineering
- Output identifier
- 1456804
- Type
- D - Journal article
- DOI
-
10.1016/j.msec.2018.07.003
- Title of journal
- Materials Science and Engineering: C
- Article number
- -
- First page
- 565
- Volume
- 92
- Issue
- -
- ISSN
- 0928-4931
- Open access status
- Compliant
- Month of publication
- July
- Year of publication
- 2018
- URL
-
-
- Supplementary information
-
https://ars.els-cdn.com/content/image/1-s2.0-S0928493117342443-mmc1.docx
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- No
- Number of additional authors
-
6
- Research group(s)
-
-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- Cancer, disease and trauma to the larynx and their treatment can lead to permanent loss of structures critical to voice, breathing and swallowing. Engineered partial or total laryngeal replacements would need to match the ambitious specifications of replicating functionality, outer biocompatibility, and permissiveness for an inner mucosal lining. Here we present a potential scaffold for engineering laryngeal tissue. Our data show that with a change in manufacturing protocol to produce porous polymer surfaces, the material may be a candidate for overcoming some of the limitations associated with laryngeal reconstruction and regeneration. In vivo studies assessing tissue compatibility are expected shortly.
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -
