Assessment of Temporal Dose-Toxicity Relationship of Fumed Silica Nanoparticle in Human Lung A549 Cells by Conventional Cytotoxicity and 1H-NMR-Based Extracellular Metabonomic Assays
- Submitting institution
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Robert Gordon University
- Unit of assessment
- 12 - Engineering
- Output identifier
- Njuguna_1
- Type
- D - Journal article
- DOI
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10.1093/toxsci/kfu009
- Title of journal
- Toxicological Sciences
- Article number
- -
- First page
- 354-364
- Volume
- 138
- Issue
- 2
- ISSN
- 1096-0929
- Open access status
- Out of scope for open access requirements
- Month of publication
- -
- Year of publication
- 2014
- URL
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- Supplementary information
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- Request cross-referral to
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- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- No
- Number of additional authors
-
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- Research group(s)
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- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- This interdisciplinary research across three UK institutes (Cranfield, RGU and Imperial College) demonstrated that the fumed silica nanoparticles (SiNPs) caused both acute and delayed cytotoxicity in A549 cells. The study also provided new insight in that SiNP-induced extracellular metabonomic alteration and toxicity both followed a cubic polynomial dose-response trend better than a linear trend. It was funded by EC (CP-FP 228536-2), contributed to award of a new project by EC Life+ (SIRENA, ENV/ES/596) and a new book ‘Health and Environmental Safety of Nanomaterials’ (ISBN 0 85709 655 9, Woodhead/Elsevier).
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -