Coincidence detection of membrane stretch and extracellular pH by the proton-sensing receptor OGR1 (GPR68)
- Submitting institution
-
University of Oxford
- Unit of assessment
- 12 - Engineering
- Output identifier
- 9563
- Type
- D - Journal article
- DOI
-
10.1016/j.cub.2018.10.046
- Title of journal
- Current Biology
- Article number
- -
- First page
- 3815
- Volume
- 28
- Issue
- 23
- ISSN
- 0960-9822
- Open access status
- Compliant
- Month of publication
- November
- Year of publication
- 2018
- URL
-
-
- Supplementary information
-
https://ars.els-cdn.com/content/image/1-s2.0-S0960982218314131-mmc1.pdf
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- Yes
- Number of additional authors
-
5
- Research group(s)
-
-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- In this publication, a neuron cell stretching device developed in the group was employed by a collaborator working in cell biology to clarify the link between the activity level of a membrane protein, OGR1, and the extent of membrane stretch and degree of extracellular acidification. With well characterised engineering design, the device has outperformed a commercial unit the collaborator purchased and provided the data necessary for the publication of the work in this highly regarded scientific journal.
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -