Microscale characterization of prostate biopsies tissues using optical coherence elastography and second harmonic generation imaging
- Submitting institution
-
University of Dundee
- Unit of assessment
- 12 - Engineering
- Output identifier
- 33466574
- Type
- D - Journal article
- DOI
-
10.1038/labinvest.2017.132
- Title of journal
- Laboratory Investigation
- Article number
- -
- First page
- 380
- Volume
- 98
- Issue
- 3
- ISSN
- 0023-6837
- Open access status
- Compliant
- Month of publication
- December
- Year of publication
- 2017
- URL
-
-
- Supplementary information
-
-
- Request cross-referral to
- 1 - Clinical Medicine
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- Yes
- Number of additional authors
-
8
- Research group(s)
-
-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- This is a first clinical study at large scale to perform a detailed analysis of the microstructural details of human PCa tissue and orientation of collagen around cancerous lesions using our novel designed system of optical coherence elastography in conjunction with second harmonic generation to provide high-resolution imaging solutions for characterization biopsy stiffness and collagen orientation together constitute the new biomechanical markers of PCa with a very high diagnostic accuracy in terms of Gleason grade of cancerous tissues. This study was supported by Scottish Universities Physics Alliance PhD studentship, Prostate Cancer UK (PCUK), and the Welcome Trust (Grant No. WT101468).
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -