Cobalt (II) ions and nanoparticles induce macrophage retention by ROS-mediated downregulation of RhoA expression
- Submitting institution
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Queen Mary University of London
- Unit of assessment
- 12 - Engineering
- Output identifier
- 2608
- Type
- D - Journal article
- DOI
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10.1016/j.actbio.2018.03.054
- Title of journal
- Acta Biomaterialia
- Article number
- -
- First page
- 434
- Volume
- 72
- Issue
- -
- ISSN
- 1878-7568
- Open access status
- Compliant
- Month of publication
- April
- Year of publication
- 2018
- URL
-
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- Supplementary information
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- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- No
- Number of additional authors
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0
- Research group(s)
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-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- This collaborative and multidiscipinary output considered macrophages, loaded with particulate debris, found around failed CoCrMo joint replacements implying a role of cobalt. This work involved industry collaboration: MatOrtho (Simon.Collins@matortho.com) and Wallwork (andy.fox@wallworkht.com). It has contributed to the Smart Spacer grant (Innovate UK, 2016, Project:102536, £841K) which utilises CrNAg coatings for knee spacer implants, first in man, designed to reduce cobalt and introduce silver as an antimicrobial agent (http://www.opnews.com/2017/09/silver-solution-infection-knee-implants/13940) in collaboration with RNOH (A.Hart@ucl.ac.uk), through evaluating toxic levels of cobalt and silver. It contributed to a PhD award (Jing Xu).
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -