A dimensionless ordered pull-through model of the mammalian lens epithelium evidences scaling across species and explains the age-dependent changes in cell density in the human lens.
- Submitting institution
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University of Durham
- Unit of assessment
- 12 - Engineering
- Output identifier
- 99943
- Type
- D - Journal article
- DOI
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10.1098/rsif.2015.0391
- Title of journal
- Journal of The Royal Society Interface
- Article number
- -
- First page
- 20150391
- Volume
- 12
- Issue
- 108
- ISSN
- 17425689
- Open access status
- Out of scope for open access requirements
- Month of publication
- -
- Year of publication
- 2015
- URL
-
https://doi.org/10.1098/rsif.2015.0391
- Supplementary information
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-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- Yes
- Number of additional authors
-
5
- Research group(s)
-
-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- Worldwide there are 40 million blind people and over half of these lost their sight due to eye lens problems. This interdisciplinary research not only addressed fundamental questions on scaling across different mammals but also the ageing of the human lens. The outcomes led to funding from Rosetrees Trust, EPSRC IAA and CN Bio Innovations Ltd (CEO: Dr David Hughes david.hughes@cn-bio.com). Together with recent international patents (Wu JJ et al European patent EP3445412; US patent US2019/0134264 and China patent CN109310804), this has enabled the development of 3D bioengineered lens for drug evaluation and potentially personalised therapies to fight blindness.
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -
