Amorphous metal-organic frameworks for drug delivery.
- Submitting institution
-
University of Cambridge
- Unit of assessment
- 12 - Engineering
- Output identifier
- 9845
- Type
- D - Journal article
- DOI
-
10.1039/c5cc05237h
- Title of journal
- Chem Commun (Camb)
- Article number
- -
- First page
- 13878
- Volume
- 51
- Issue
- 73
- ISSN
- 1364-548X
- Open access status
- Out of scope for open access requirements
- Month of publication
- -
- Year of publication
- 2015
- URL
-
-
- Supplementary information
-
-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- No
- Number of additional authors
-
6
- Research group(s)
-
-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- First example of a highly porous and amorphous metal-organic framework (MOF) for small molecule drug delivery, showing high loading capacity and extended drug-release times (typical MOFs, 48h release; our material, 30+ days). This was proof of concept for a 1.9m H2020 ERC grant (NanoMOFdeli, ERC-2016-COG 726380). It also produced the foundation for a spin-out from my lab, Tarsis Technologies (Chief Commercialisation Officer Frontier IP Group plc), the delivery of pesticides and exploiting this IP (PCT/EP2016/064746). It formed the basis of 10.1021/acsami.7b07342, /10.1002/adhm.201600296, 10.1039/C6TB02025A, 10.1021/jacs.7b01451 and 10.1021/acsami.9b21692 and opened collaborations in drug delivery with Profs. Forgan (Glasgow), Farha (Northwestern); Stock (Kiel).
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -