A multiscale model to predict current absolute risk of femoral fracture in a postmenopausal population
- Submitting institution
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The University of Sheffield
- Unit of assessment
- 12 - Engineering
- Output identifier
- 2682
- Type
- D - Journal article
- DOI
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10.1007/s10237-018-1081-0
- Title of journal
- Biomechanics and Modeling in Mechanobiology
- Article number
- -
- First page
- 301
- Volume
- 18
- Issue
- 2
- ISSN
- 1617-7959
- Open access status
- Compliant
- Month of publication
- October
- Year of publication
- 2018
- URL
-
-
- Supplementary information
-
-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- No
- Number of additional authors
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3
- Research group(s)
-
-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- A model of the absolute risk of current hip fracture ARF0 is introduced. Its novelty lies in mechanistically combining models for fall frequency, fall severity and bone strength, while accounting for scale separation across, and natural stochasticity within, these models. The ARF0 model and its component models are individually verified, uncertainty quantified, sensitivity analysed and validated against observations. This generates new understanding and can significantly improve healthcare outcomes: 4 million people worldwide sustain a hip fracture annually, yet only 2% have osteoporosis. The ARF0 model importantly has a 10-percentage point higher accuracy in classifying hip fracture status (compared to standard-of-care).
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -