Guiding the folding pathway of DNA origami.
- Submitting institution
-
University of Oxford
- Unit of assessment
- 11 - Computer Science and Informatics
- Output identifier
- 1958
- Type
- D - Journal article
- DOI
-
-
- Title of journal
- Nature
- Article number
- -
- First page
- 82
- Volume
- 525
- Issue
- 7567
- ISSN
- 0028-0836
- Open access status
- Out of scope for open access requirements
- Month of publication
- August
- Year of publication
- 2015
- URL
-
-
- Supplementary information
-
https://www.nature.com/articles/nature14860#Sec13
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- Yes
- Number of additional authors
-
5
- Research group(s)
-
-
- Citation count
- 92
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- DNA �origami� folding is a novel experimental technology for programmable manufacture of nanoscale structures, such as a tile on whose surface a �DNA walker� can perform computation to detect a substance or deliver cargo. To understand the principles behind folding, a novel large abstract inhomogeneous Markov chain model (see Methods https://www.nature.com/articles/nature14860#methods) is devised and parameterised based on experimental kinetic rate data. Despite the abstraction of the model, an analysis using Dijkstra�s algorithm and Gillespie�s simulation can predict the behaviour and gives insight into the assembly process. The results have subsequently been corroborated, e.g., ACS Nano�20 (https://doi.org/10.1021/acsnano.9b09348), Nucleic Acids Research�20 (https://doi.org/10.1093/nar/gkaa283).
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -