Differential Integrin Expression Regulates Cell Sensing of the Matrix Nanoscale Geometry
- Submitting institution
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Queen Mary University of London
- Unit of assessment
- 12 - Engineering
- Output identifier
- 592
- Type
- D - Journal article
- DOI
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10.1016/j.actbio.2016.11.069
- Title of journal
- Acta Biomaterialia
- Article number
- -
- First page
- 280
- Volume
- 50
- Issue
- -
- ISSN
- 1878-7568
- Open access status
- Compliant
- Month of publication
- December
- Year of publication
- 2016
- URL
-
-
- Supplementary information
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- Request cross-referral to
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- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- No
- Number of additional authors
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4
- Research group(s)
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-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- In this work we demonstrate that the expression of different integrins modulate cell response to nanoscale geometry and topography. This led to the identification of differential integrin expression as a potential modulator of stem cell phenotype in response to changes in the extra-cellular environment. 7 invited talks (Newcastle 2016, AFPM2016, Sheffield 2016, Heidelberg 2017, ICMAT2017, Hubrecht Institute 2018, Nijmegen 2018). Invited to write 1 book chapter on cellular sensing of physical properties of ECM and 1 review in Acta Biomater (https://pubmed.ncbi.nlm.nih.gov/26596568/). 1 successful research grant from Leverhulme Trust (£250k) to develop nanofiber reinforced liquid interfaces for stem cell culture.
- Author contribution statement
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- Non-English
- No
- English abstract
- -