An in vitro model for studying CNS white matter: functional properties and experimental approaches
- Submitting institution
-
Heriot-Watt University
(joint submission with University of Edinburgh)
- Unit of assessment
- 12 - Engineering
- Output identifier
- 24328922
- Type
- D - Journal article
- DOI
-
10.12688/f1000research.16802.1
- Title of journal
- F1000Research
- Article number
- 117
- First page
- -
- Volume
- 8
- Issue
- -
- ISSN
- 2046-1402
- Open access status
- Compliant
- Month of publication
- January
- Year of publication
- 2019
- URL
-
-
- Supplementary information
-
-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- Yes
- Number of additional authors
-
13
- Research group(s)
-
-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- We describe a new dynamic approach to assessing myelination in vitro by measuring cell electrical signalling directly in multiple sclerosis research. It has reduced the number of animals necessary for this work, and improved insight into the disease condition. Our engineered solution of microelectrode arrays combined with microfluidics is currently in discussion for commercialisation [Contact: Managing Director, Epigem Ltd.], while ongoing research is funded by the Multiple Sclerosis Society (joint with the University of Glasgow, award no. 127) [Contact: MS Society].
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -
