Modeling the evolution space of breakage fusion bridge cycles with a stochastic folding process
- Submitting institution
-
The University of East Anglia
- Unit of assessment
- 11 - Computer Science and Informatics
- Output identifier
- 182619822
- Type
- D - Journal article
- DOI
-
10.1007/s00285-015-0875-2
- Title of journal
- Journal of Mathematical Biology
- Article number
- -
- First page
- 47
- Volume
- 72
- Issue
- 1
- ISSN
- 0303-6812
- Open access status
- Out of scope for open access requirements
- Month of publication
- January
- Year of publication
- 2016
- URL
-
-
- Supplementary information
-
-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- Yes
- Number of additional authors
-
4
- Research group(s)
-
-
- Citation count
- 7
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- This paper provides a full account of the combinatorics of breakage-fusion-bridge rearrangements found in genomes from grass to cancer. It has seen applications to breast cancer genomics (Ferrari, 2016), ovarian cancer (Papp, 2018), and linked to the chromothripsis process (Pellman, 2017). Parallel techniques have also been developed for tandem duplication processes (Dolfin 2015), and for general rearrangement processes (Greenman, 2020). Presented at an invited talk (Warwick, systems biology group, 2017). PhD examination resulted in development of recent collaboration (Barnes, UCL).
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -