Additive manufactured biodegradable poly(glycerol sebacate methacrylate) nerve guidance conduits
- Submitting institution
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The University of Sheffield
- Unit of assessment
- 12 - Engineering
- Output identifier
- 5854
- Type
- D - Journal article
- DOI
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10.1016/j.actbio.2018.07.055
- Title of journal
- Acta Biomaterialia
- Article number
- -
- First page
- 48
- Volume
- 78
- Issue
- -
- ISSN
- 1742-7061
- Open access status
- Compliant
- Month of publication
- August
- Year of publication
- 2018
- URL
-
-
- Supplementary information
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-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- No
- Number of additional authors
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5
- Research group(s)
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-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- We highlight the first in vivo study of poly(glycerol sebacate methacrylate(PGSM))-based nerve guidance conduits (NGCs). We explored this biodegradable elastomer for peripheral nerve repair and studied regeneration in a mouse model. Excellent nerve regeneration has been achieved with these NGCs, comparable to autografts, the gold standard. This study is being rapidly assimilated in NGC literature and is reported in recent topical reviews and papers (doi.org/10.1021/acschemneuro.9b00203, doi.org/10.1016/j.actbio.2019.03.047), while the work on PGSM spawned further work on materials development (doi.org/10.1002/adfm.201910391). We are investigating use of PGSM as coating for vascular stent-grafts with Terumo Aortic, a leading vascular devices company (contact: R&D Manager).
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -