Deep tissue volume imaging of birefringence through fibre-optic needle probes for the delineation of breast tumour
- Submitting institution
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The University of Surrey
- Unit of assessment
- 12 - Engineering
- Output identifier
- 9024876_1
- Type
- D - Journal article
- DOI
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10.1038/srep28771
- Title of journal
- Scientific Reports
- Article number
- 28771
- First page
- -
- Volume
- 6
- Issue
- 1
- ISSN
- 2045-2322
- Open access status
- Compliant
- Month of publication
- -
- Year of publication
- 2016
- URL
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- Supplementary information
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- Request cross-referral to
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- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- No
- Number of additional authors
-
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- Research group(s)
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- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- 25% of lumpectomy operations to remove breast tumours require repeat operations due to “positive” margins (tumour detected at the border), causing unnecessary patient trauma and cost. Optical coherence tomography (OCT) in a hypodermic needle might detect and avoid positive margins but differentiating cancerous from fibrous benign tissue is often not possible. Birefringence, if localised, could provide extra contrast to achieve this. By combining needle optics, with polarisation-sensitive OCT, we were the first to demonstrate such contrast. This work contributed to the formation of a spin out company, Miniprobes (robert.mclaughlin@miniprobes.com), and featured in more than 20 invited talks.
- Author contribution statement
- -
- Non-English
- No
- English abstract
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