An in vitro model for the development of mature bone containing an osteocyte network
- Submitting institution
-
The University of Birmingham
- Unit of assessment
- 12 - Engineering
- Output identifier
- 50433563
- Type
- D - Journal article
- DOI
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10.1002/adbi.201700156
- Title of journal
- Advanced Biosystems
- Article number
- 1700156
- First page
- -
- Volume
- 2
- Issue
- 2
- ISSN
- 2366-7478
- Open access status
- Compliant
- Month of publication
- December
- Year of publication
- 2017
- URL
-
-
- Supplementary information
-
-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- Yes
- Number of additional authors
-
9
- Research group(s)
-
-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- Current methods for growing bone in the lab are limited in two ways; they don’t produce structures that reproduce the complexity of real bone and can only allow the possibility of keeping the predominant cell type (osteocyte) in bone alive for 14 days. This ground-breaking work describes a method for the production of bone, which recapitulates the structure of mature bone and allows for maintenance of osteocytes for significantly longer; up to one year following isolation. Utilising the model presented here, enabled identification of a number of molecules that can modify the bone formation process, without expansive animal experiments.
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -