A Novel Approach to Ultrasound-Mediated Tissue Decellularization and Intra-Hepatic Cell Delivery in Rats
- Submitting institution
-
University College London
- Unit of assessment
- 12 - Engineering
- Output identifier
- 12287
- Type
- D - Journal article
- DOI
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10.1016/j.ultrasmedbio.2016.03.020
- Title of journal
- Ultrasound in Medicine and Biology
- Article number
- -
- First page
- 1958
- Volume
- 42
- Issue
- 8
- ISSN
- 0301-5629
- Open access status
- Out of scope for open access requirements
- Month of publication
- May
- Year of publication
- 2016
- URL
-
-
- Supplementary information
-
-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- No
- Number of additional authors
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4
- Research group(s)
-
-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- In this paper we prove the feasibility of an exciting novel cell therapy approach for the treatment of thus far incurable liver diseases, such as paediatric metabolic liver disease and cirrhosis. The results prove that the cavity created non-invasively using ultrasonic histotripsy (or tissue emulsification) is a suitable environment for the proliferation of injected primary hepatocytes. The cell implantation led to the recovery of liver function in rats after only 1 week post treatment. This is ground breaking. Next stage of the work is being planned with liver surgeons (Prof. B. Davidson, Royal Free Hospital, b.davidson@ucl.ac.uk) for possible first-in-man studies.
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -