Genome-wide posttranscriptional dysregulation by microRNAs in human asthma as revealed by Frac-seq.
- Submitting institution
-
University of Southampton
- Unit of assessment
- 11 - Computer Science and Informatics
- Output identifier
- 54504934
- Type
- D - Journal article
- DOI
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10.4049/jimmunol.1701798
- Title of journal
- The Journal of Immunology
- Article number
- -
- First page
- 251
- Volume
- 201
- Issue
- 1
- ISSN
- 0022-1767
- Open access status
- Access exception
- Month of publication
- May
- Year of publication
- 2018
- URL
-
-
- Supplementary information
-
-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- Yes
- Number of additional authors
-
6
- Research group(s)
-
-
- Citation count
- 14
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- This is an interdisciplinary study, starting from a computational model of the link between transcriptome and proteome (https://tinyurl.com/uapyxln) and carries out experimental work using the technique of Frac-seq. It identifies precise molecular mechanisms of regulation by micro RNAs that regulate protein translation speeds, with significant and rigorous computational input in: (a) the model-based arguments that established the experimental work; and (b) in processing vast volumes of data for generating hypothesis on molecular regulations.
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -