One-step continuous extrusion process for the manufacturing of solid dispersions
- Submitting institution
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University of Greenwich
- Unit of assessment
- 12 - Engineering
- Output identifier
- 14553
- Type
- D - Journal article
- DOI
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10.1016/j.ijpharm.2015.09.048
- Title of journal
- International Journal of Pharmaceutics
- Article number
- -
- First page
- 42
- Volume
- 496
- Issue
- 1
- ISSN
- 0378-5173
- Open access status
- Out of scope for open access requirements
- Month of publication
- -
- Year of publication
- 2015
- URL
-
-
- Supplementary information
-
-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- No
- Number of additional authors
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5
- Research group(s)
-
-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- A novel inorganic carrier in hot melt extrusion processing of indomethacin was developed for solid dispersions, which can generate porous network of the inorganic material for all extruded formulations. It demonstrated that inorganic excipients (synthetic magnesium aluminometasilicate) can be successfully used as carriers to manufacture amorphous solid dispersions with enhanced dissolution rates of poorly water-soluble drugs. It also shows potentials for new drug formulation development and new drug development. This work was financially supported by Fuji Chemical Industry Co., Ltd., Japan. This work led to further consultancy projects in pharmaceutical industry.
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -
